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KMID : 0191120110260060807
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Journal of Korean Medical Science
2011 Volume.26 No. 6 p.807 ~ p.813
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Prostate Volume has Prognostic Value Only in Pathologic T2 Radical Prostatectomy Specimens
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Cho In-Chang
Kwon Whi-An
Kim Jeong-Eun
Joung Jae-Young
Seo Ho-Kyung
Chung Jin-Soo
Park Weon-Seo
Lee Kang-Hyun
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Abstract
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The objective of this study was to evaluate the prognostic roles of the prostate volume, tumor volume, and tumor percentage as a function of the pathologic T stage in radical prostatectomy specimens. This study included 259 patients who underwent radical prostatectomy between 2005 and 2010. The mean follow-up period was 41.2 months. In all of the specimens, prostate volume (P = 0.021), the Gleason score (P = 0.035), and seminal vesicle invasion (P = 0.012) were independent predictors of biochemical recurrence (BCR). In the T2 group, multivariate analysis showed that the BCR was significantly associated with prostate specific antigen (PSA) (P = 0.028), a lower prostate volume (P = 0.004), and the Gleason score (P = 0.040). The Kaplan-Meier survival curve showed that a smaller prostate volume was significantly associated with a greater risk of BCR (< 30 vs ≥ 30 mL; P = 0.010). In the T3 group, patients with seminal vesicle invasion had a significantly shorter mean BCR-free survival (P = 0.030). In this study, tumor volume and tumor percentage did not predict BCR. Notably, a lower prostate volume is an independent predictor for BCR only in the organ-confined radical prostatectomy specimens. But, prostate volume could not predict BCR in most locally advanced tumors.
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KEYWORD
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Prostate, Prostatic Neoplasms, Prostatectomy, Volume
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